Survivin, MMP-2, and MMP-9 expression in different types of cervical lesions and correlation analysis

To analyze Survivin, MMP-2, and MMP-9 expression in different types of cervical lesions and discuss their correlation and clinical significance. Patients with chronic cervicitis, cervical intraepithelial neoplasia, or cervical cancer in our hospital were collected. ELISA was applied to detect the level of Survivin, MMP-2 and MMP-9 in serum. Immunohistochemistry was used to measure Survivin, MMP-2 and MMP-9 expression in tissue. Their correlation was analyzed. Survivin, MMP-2, and MMP-9 were overexpressed in chronic cervicitis, cervical intraepithelial neoplasia, and cervical cancer (P < 0.05). Their levels were related to pathological grade, clinical stage, differentiation, vascular invasion, and lymph node metastasis (P < 0.05), but not age, gross type, and histological type (P > 0.05). Their levels were elevated significantly following increased pathologic classification, clinical upstage, lower differentiation degree, vascular invasion and lymph node metastasis emergence. Survivin, MMP-2, and MMP-9 showed escalating trend in the serum and cervical tissue of chronic cervicitis, cervical intraepithelial neoplasia, and cervical cancer patients. They were highly expressed in cervical cancer patients’ serum and tissue. Their levels were correlated with pathological grade, clinical stage, differentiation, vascular invasion, and lymph node metastasis, and showed obvious elevation.